Personalized Auricular Non-invasive Vagus Nerve Stimulation System for Inflammatory Bowel Disease Treatment

Abstract: Inflammatory bowel disease (IBD) is a chronic relapsing clinic condition whose cure could be very difficult even with new treatments. Although tremendous changes have occured in IBD treatment; there is an unmet need for a low-cost, easy-to-access treatment associated with low side effects. Possible dysfunction of interaction between the microbiome-gut-brain axis and autonomic nervous system; expecially vagus nerve dysfunction can be targeted for a new therapy. Given this, vagus nerve stimulation (VNS) camoes to the fore. Using present literature, we reviewed pathophysiology of IBD and anti inflammatory effect of VNS and the current aim of this review is to provide a comprehensive understanding of the effect of VNS on gut inflammation and the potential of personalized auricular VNS on IBD management. In the field of precision medicine these days, when digital transformation in health comes to the fore, personalized auricular VNS which uses machine learning algortims may be an complementary treatment of IBD.

Keywords: Autonomic nervous system; complementary medicine; inflammatory bowel disease; vagus nerve stimulation

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